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Adjunct drugs such as catechol-O-methyltransferase (COMT) and monoamine oxidase-B (MAO-B) inhibitors lack specificity to the central nervous system (CNS), have poor BBB permeability, and result in systemic side effects 15,16
Toxicol Lett 215:4041
Rat research found 38.4% oral bioavailability, but no human study has compared the two routes
Increase in glutathione disulfide level regulates the activity of microsomal [PMID: 2619745] Laboratory literature summary: Increase in glutathione disulfide level regulates the activity of microsomal glutathione S-transferase in rat liver
Shields HJ, Traa A, Van Raamsdonk JM
Approved medical uses include: Growth hormone deficiency HIV-related wasting Short stature in children However, using HGH for performance enhancement, anti-aging, or physique goals is not approved by the FDA and is considered illegal
